Dexmedetomidine vs Propofol Sedation Reduces Postoperative Delirium in Patients Receiving Hip Arthroplasty.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 296
- 试验地点
- 1
- 主要终点
- Incidence of postoperative delirium
研究概览
简要总结
With blocks of lumbar and lumbar plexus, we can reduce the intravenous anesthetics usage. To offer an satisfied surgery process for patients, a proper sedation is necessary. So in this study, we want to investigate the influence of two different sedative drugs on outcomes of patients received hip replacement surgery .
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Triple (Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 65 Years 至 85 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •65 years or older and undergoing hip fracture repair
排除标准
- •Patients with severe cognitive impairment (MMSE score, <15)
- •Preoperative delirium as determined by Confusion Assessment Method
- •Contraindications to local anesthesia
- •Prior hip surgery
- •Mental or language barriers that would preclude data collection
- •Severe congestive heart failure (NewYork Heart Association class IV)
- •Severe chronic obstructive pulmonary disease (Global Initiative for Chronic Obstructive Lung Disease guidelines, stage III-IV)
研究组 & 干预措施
dexmedetomidine sedation
Patients received local anesthesia, in this arm, the sedation of patients was achieved with a bolus of dexmedetomidine at 1.0 μg/kg (over a period of 15 to 20 min) and followed by an infusion of dexmedetomidine at 0.2-0.7 μg/kg/h.
干预措施: dexmedetomidine (Drug)
propofol sedation
Patients received local anesthesia, in this arm, the sedation of patients was achieved with a target-controlled infusion (TCI) of propofol, and the effect site concentration was set to 0.8-1.0μg/ml.
干预措施: propofol (Drug)
结局指标
主要结局
Incidence of postoperative delirium
时间窗: 7 days after surgery
Mortality in 30 days after surgery
时间窗: 30 days after surgery
次要结局
- Complications of cardiopulmonary system(30 days after surgery)
- Incidence of cerebrovascular accident(30 days after surgery)
- Dosage of vasoactive agent(During sugary)
- Discharge time(30 days after surgery)
- Hemodynamic index(intraoperative)
- Extubation time(7 days after surgery)
- Out of bed time(7 days after surgery)