Comparative Study on the Effects of Epidural Dexmedetomidine on Heart Rate Variability During General Anesthesia in Patients Undergoing Gastrectomy
Overview
- Phase
- Not Applicable
- Intervention
- preemptive dexmedetomidine epidural bolus injection(1.5 mcg/kg)
- Conditions
- Gastric Cancer
- Sponsor
- Yonsei University
- Enrollment
- 38
- Locations
- 1
- Primary Endpoint
- Heart rate variability analysis
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
The use of epidural dexmedetomidine decreases the anaesthetic requirements and improved postoperative pain. Dexmedetomidine is a potent and highly selective a2-adrenoceptor agonist and has sympatholytic effect. Power spectral analysis of heart rate variability(HRV) is a useful tool to assess cardiac autonomic activity. We investigated whether preemptive epidural dexmedetomidine can develop hemodynamic change and it could be identify patients by HRV.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients consented to spinal anesthesia were enrolled
- •Patients aged 40\~70 years olds undergoing gastrectomy
- •No contraindication of epidural analgesia
- •ASA class I and II
- •Patients consented to epidural anesthesia were enrolled
Exclusion Criteria
- •Patients with hypovolemia, coagulation disorders, local infection at the site of operation, history of headache, heart diseases, and history of allergy, chronic alcohol use or abuse, anemia, congenital heart diseases, bundle block, congestive heart failure or arrythmias
- •patients who had recently received sedative drugs or were under antidepressant treatment were not included in the study
Arms & Interventions
dexmedetomidine
Intervention: preemptive dexmedetomidine epidural bolus injection(1.5 mcg/kg)
normal saline
Intervention: normal saline
Outcomes
Primary Outcomes
Heart rate variability analysis
Time Frame: 5min perioids after fluid resuscitation.
Heart rate variability analysis was performed according to the Task Force recommendations. Frequency domain analysis was based on fast Fourier transformation. Power spectrum densities were calculated for low frequencies (LF: 0.04-0.15 Hz) and high frequencies (HF: 0.15-0.4 Hz) informalized units, defined as the LF or HF proportional part of the total power. Baseline and 30min after the injection of the study drug.
Secondary Outcomes
- Epidural injection(at 30 min after the epidural injection of the study drug)