Anesthetic Advantages of Dexmedetomidine Compared With Nitroglycerin for Hypotensive Anesthesia in Orthognathic Surgery. A Randomized Clinical Trial.
Overview
- Phase
- Not Applicable
- Intervention
- Dexmedetomidine
- Conditions
- Anesthesia
- Sponsor
- Mahidol University
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- amount of intraoperative fentanyl
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
The aim of this study was to evaluate the positive anesthetic properties such as reduce intraoperative analgesic requirement, time to extubation and recovery, and early postoperative pain of dexmedetomidine used as a hypotensive agent compared with nitroglycerin.
Detailed Description
The subject included the healthy patients who underwent orthognathic surgery and gave written the informed consent. The sample size was calculate from the amount of fentanyl use in orthognathic surgical case and difference more 30% was significant. Randomization was done by random number table to 2 groups. Both groups received standardized controlled hypotensive anesthesia and surgery. D group used dexmedetomidine as the hypotensive drug and N group use nitroglycerin. The main outcome were the amount of fentanyl use, time to eye opening, follow simple command, extubation, early postoperative pain, and early postoperative amount of pain killer. All recorded by anesthesiologist on data sheet. compare statistical analysis used compare mean by unpaired student t test.
Investigators
Duangdee Rummasak
department of oral and maxillofacial surgery, faculty of dentistry
Mahidol University
Eligibility Criteria
Inclusion Criteria
- •patients who undergo bimaxillary surgery physical status I according to the classification of the American Society of Anesthesiologist age 18-45 years
Exclusion Criteria
- •systemic diseases not given informed consent
Arms & Interventions
dexmedetomidine
Intraoperative controlled hypotension by dexmedetomidine
Intervention: Dexmedetomidine
nitroglycerin
Intraoperative controlled hypotension by nitroglycerin
Intervention: Nitroglycerin
Outcomes
Primary Outcomes
amount of intraoperative fentanyl
Time Frame: intraoperatve period
Record the amount of fentanyl used in the operation.
Secondary Outcomes
- time to eye opening(emergence of anesthesia)
- time to follow verbal command(emergence of anesthesia)
- time to extubation(emergence of anesthesia)
- postoperative pain score at 30 minute(early postoperative period)
- postoperative pain score at 60 minute(early postoperative period)
- amount of pethidine(early postoperative period (first 2 hours))