Comparison of Epidural Dexmedetomidine and Dexamethasone as an Adjuvant to Ropivacaine on Postoperative Pain Level, Analgesic Consumption and Oxidative Stress in Thoracic Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Dexmedetomidine Injection [Precedex]
- Conditions
- Pain, Postoperative
- Sponsor
- University Hospital Dubrava
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Change in postoperative pain level using visual analogue scale
- Last Updated
- 7 years ago
Overview
Brief Summary
The aim of the study is to investigate the effect of preoperative epidural dexmedetomidine compared to dexamethasone on postoperative pain control, analgesic consumption and oxydative stress response in patients undergoing thoracic surgery
Detailed Description
The aim of the study is to investigate the effect of preoperative epidural dexmedetomidine compared to dexamethasone on postoperative pain control, analgesic consumption and oxydative stress response in patients undergoing thoracic surgery. Investigation will include patients between 30-70 years undergoing thoracic surgery due to malignant process of lung or oesophagus. Patients are divided in two groups: epidural administration of 0.375% ropivacaine with 1 mcg/kg dexmedetomidine (group 1) and epidural administration of 0.375% ropivacaine with 8 mg dexamethasone.
Investigators
Jasminka Persec, MD, PhD
Assist Prof MD PhD
University Hospital Dubrava
Eligibility Criteria
Inclusion Criteria
- •patients undergoing thoracic surgery due to malignant process of lung or oesophagus ASA (American Society of Anesthesiologists) status I-III
Exclusion Criteria
- •neurological or psychiatric disease
- •corticosteroid therapy
- •anamnesis of myocardial infarct within last 6 months
- •severe aortic stenosis
- •kidney insufficiency
- •liver insufficiency
- •coagulation disorders
Arms & Interventions
Dexmedetomidine
1 mcg/kg dexmedetomidine added to 8 ml 0.375% ropivacaine
Intervention: Dexmedetomidine Injection [Precedex]
Dexamethasone
8 mg dexamethasone added to 8 ml 0,375% ropivacaine
Intervention: Dexmedetomidine Injection [Precedex]
Outcomes
Primary Outcomes
Change in postoperative pain level using visual analogue scale
Time Frame: Before operation, 1 hour, 2 hour, 6 hour and 24 hour after operation
Change in baseline postoperative pain level measured before operation, and then at 1h, 2h, 6h and 24h after operation using visual analogue scale. Visual analogue scale is numerical scale in range from 1-10, assessing pain level. Minimum score is 1, which represents- no pain to maximum score 10 which represents- the worst pain ever experienced.
Secondary Outcomes
- oxydative stress level(24 hour)
- analgesic consumption(24 hour)