A study to assess the toxicity of chlorhexidine in orthodontic patients
Phase 3
- Conditions
- Health Condition 1: M269- Dentofacial anomaly, unspecified
- Registration Number
- CTRI/2019/08/020495
- Lead Sponsor
- Farheen Akhtar
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Closed to Recruitment of Participants
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients in the age group of 12-30 years
Clinically healthy patients with no systemic illness
Patients with no previous history of orthodontic treatment
Not receiving any antibiotics, anti-inflammatory or multivitamin supplements for last 3 months
Exclusion Criteria
Patients with syndromes and debilitating diseases
Mucosal lesions anywhere in the oral cavity
Smokers and tobacco chewers
Patients with prosthesis or restorations
Allergy to costume jewellery, watches, or sources of nickel and chromium
Occupational exposure to metals
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Plaque index <br/ ><br>Bleeding on probing <br/ ><br>Probing Pocket Depth <br/ ><br>Clinical Attachment level <br/ ><br>Comet Assay <br/ ><br>Micronucleus test <br/ ><br>Timepoint: 0 weeks, 2 weeks, 6 weeks, 12 weeks
- Secondary Outcome Measures
Name Time Method Trypan blue exclusion dye testTimepoint: 0 weeks, 2 weeks, 6 weeks, 12 weeks