Iodine Status and Characteristics of Papillary Thyroid Cancer

Not yet recruiting

• Conditions: Papillary Thyroid Carcinoma
• Interventions: Dietary Supplement: Iodine excess; Dietary Supplement: Iodine suitable

• Registration Number: NCT06626581
• Lead Sponsor: Shandong Provincial Hospital

Brief Summary

The effect of iodine on papillary thyroid cancer has been controversial for many years. The investigators designed a cross-sectional study and aimed to explore the relationship between the serum and urine iodine levels and the clinical and molecular characteristics of papillary thyroid cancer.

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-09
• Study First Submitted: 2024-09-25
• Study First Submitted QC: 2024-10-03
• Last Update Submitted: 2024-10-03
• Study First Posted: 2024-10-04
• Last Update Posted: 2024-10-04
• Study Start: 2024-11-01
• Primary Completion: 2026-11-01
• Study Completion: 2026-12-31

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 600

Inclusion Criteria

• Age range: 18~65 years old, gender not limited;
• Living in the residential area for at least 5 years;
• Patients diagnosed clinically with thyroid cancer and scheduled for thyroid surgery, with pathological diagnosis of papillary thyroid cancer;
• Complete clinical data: including general information, relevant laboratory tests, pathological reports, surgical reports, ultrasound reports, etc.

Exclusion Criteria

• Pathological diagnosis of other types of thyroid cancer;
• Diagnosed with other types of cancer;
• There are serious comorbidities of the heart, liver, and kidneys;

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Excessive iodine group	Iodine excess	Residents with papillary thyroid cancer who have lived in excessive iodine areas for a long time (5 years or more). According to the report of Shandong linstitute of Endemic Disease Prevention and Control, three sub centers were selected in excessive iodine group(Jining/Liaocheng/Heze).
Suitable iodine group	Iodine suitable	Residents with papillary thyroid cancer who have lived in suitable iodine areas for a long time (5 years or more). According to the report of Shandong linstitute of Endemic Disease Prevention and Control, three sub centers were selected in suitable iodine group(Jinan/Shenyang/Haerbin).

Primary Outcome Measures

Name	Time	Method
Serum and urine iodine levels	1 year from enrollment
TNM staging of papillary thyroid cancer	3 month from enrollment