Evening versus Morning Administration of Levothyroxine: a randomised controlled double-blind trial
- Conditions
- hypothyroidism, bedtime levothyroxine, quality of lifeHypothyroidism --> hypothyreoidieBedtime levothyroxine --> inname levothyroxine voor het slapengaan
- Registration Number
- NL-OMON26022
- Lead Sponsor
- Medisch Centrum Rijnmond-Zuid
- Brief Summary
Clin Endocrinol (Oxf). 2007 Jan;66(1):43-8 Effects of evening vs morning thyroxine ingestion on serum thyroid hormone profiles in hypothyroid patients.Bolk N, Visser TJ, Kalsbeek A, van Domburg RT, Berghout A.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
1. Patients with primary hypothyroidism;
2. Above the age of 18 years old;
3. On a stable regimen of levothyroxine for at least 6 months.
Exclusion Criteria
1. Pregnancy;
2. Disease of the stomach;
3. Jejunum or ileum;
4. Use of medication known to interfere with the uptake of levothyroxine
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Significant change in TSH and thyroid hormones FT4/T3
- Secondary Outcome Measures
Name Time Method 1 Change in:<br>a. blood pressure;<br>b. pulse;<br>c. weight;<br>d. other lab results (creatinine, lipids);<br>2. Change in quality of life;<br>3. Symptoms of hypo-or hyperthyroidism.