Effect of magnesium sulphate on blood pressure fluctuations during liver transplantatio
Not Applicable
- Conditions
- Health Condition 1: I958- Other hypotension
- Registration Number
- CTRI/2021/06/034339
- Lead Sponsor
- Institute of liver and biliary sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Adult patients (18-65 years) undergoing living donor liver transplant in Institute of Liver and Biliary Sciences
Exclusion Criteria
Patient refusal.
Paediatric patients.
Acute liver failure.
Patients with serum magnesium more than 2.2 mg/dl.
Patient with severe cardiac dysfunction. [EF <45%, with regional wall motion abnormalities, asymmetric septal hypertrophy (septal/free wall ratio >1:3), Atrial Fibrillation with rapid ventricular response ( >100 beats/min)].
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Study the effect of magnesium sulphate on the incidence of post reperfusion syndrome and compare it with the control (placebo group). <br/ ><br>Timepoint: every minute of first 5 minute after reperfusion of liver allograft
- Secondary Outcome Measures
Name Time Method 1. Requirement of rescue vasopressor at the time of reperfusion (upto5 mins) and post-reperfusion till the end of surgery. <br/ ><br>2. Compare Serum Lactate levels till end of surgery. <br/ ><br>3. Compare serum magnesium among both groups. <br/ ><br>4. Compare serum C-Reactive Protein (CRP) among both groups. <br/ ><br>5. Length of intensive care unit (ICU) and hospital stay <br/ ><br>Timepoint: Baseline, 30 minutes after anhepatic phase, 5minute post reperfusion, 30 minute after reperfusion, 2 hr after reperfusion, end of surgery, 24 hrs after surgery