Effect of Meal Patterning on Carotenoid Absorption From Vegetables
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 6
- 主要终点
- Area under the concentration (AUC) vs time curve for carotenoids in the triglyceride-rich lipoprotein (TRL) fraction of plasma.
研究概览
简要总结
The purpose of this research study is to determine how different meal patterns influence the absorption of beneficial plant pigments (carotenoids) from vegetables. The hypothesis is that carotenoid absorption will be lower when daily vegetables are consumed in one meal compared two smaller meals throughout the day.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Age range: 18-50 years
- •Body mass index (BMI: weight (kg)/height (m2)) ranging from 20-29 kg/m²
- •Weight stable (<4.5 kg change within the last 3 months)
- •Constant habitual activity pattern, not to exceed activities of a recreational level over the past 3 months
- •Have clinically normal blood profiles (specifically normal liver and kidney functions and fasting blood glucose of ≤110 mg/dl)
- •Non-smoking
- •Non-diabetic
- •No current use of medication affecting lipid profile
- •No intestinal disorders including lipid malabsorption, lactose intolerance
- •No heavy consumption of alcohol (>2 drinks per day)
- •No current use of dietary supplements that affect cholesterol, (e.g. Benocol or fiber supplements) or a willingness to discontinue their use during the study
排除标准
- •Use of lipid altering medications
研究组 & 干预措施
Meal Pattern Treatment A
A large vegetable salad (262g) and with a moderate amount of canola oil (8g) was consumed over a two meal period as designated by treatment group A.
干预措施: Meal Pattern Treatment A (Other)
Meal Pattern Treatment B
A large vegetable salad (262g) and with a moderate amount of canola oil (8g) was consumed over a two meal period as designated by treatment group B.
干预措施: Meal Pattern Treatment B (Other)
Treatment Group C
A large vegetable salad (262g) and with a moderate amount of canola oil (8g) was consumed over a two meal period as designated by treatment group C.
干预措施: Meal Pattern Treatment C (Other)
结局指标
主要结局
Area under the concentration (AUC) vs time curve for carotenoids in the triglyceride-rich lipoprotein (TRL) fraction of plasma.
时间窗: 0, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12 hours post dose
次要结局
未报告次要终点
研究者
Wayne Campbell
Prof. Foods and Nutrition
Purdue University