Development Cellular Models of the Ear and Nose to Study the Mechanisms of Hearing

Recruiting

• Conditions: Hearing Loss, GJB2, Cis Regulation, DFNB1

• Registration Number: NCT04823195
• Lead Sponsor: University Hospital, Brest

Brief Summary

Development of cells culturesissued from Nose and Ear to study auditory mecanisms.

Study of the cis-Modulation of the gene GJB2 for the patients with early presbycusis to identify the genetic cause of hearing loss.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-03-29
• Study First Submitted QC: 2021-03-29
• Study First Posted: 2021-03-30
• Study Start: 2021-06-15
• Status Verified: 2023-09
• Last Update Submitted: 2023-09-15
• Last Update Posted: 2023-09-18
• Primary Completion: 2024-06-15
• Study Completion: 2024-06-15

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Hearing loss Presbycusis Exostosis

Exclusion Criteria

• Genetic hearing loss

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
GJB2 cis regulation	2 years	Culture cell model

Trial Locations

Locations (1)

CHRU de Brest; 🇫🇷 Brest, France