Study of Viral Transduction of Human Auditory Sensory Cells for the Development of Gene Therapy
Recruiting
- Conditions
- Hearing Loss, Sensorineural
- Interventions
- Other: Peroperative collect of inner ear cells
- Registration Number
- NCT03996824
- Lead Sponsor
- Institut Pasteur
- Brief Summary
Gene therapy is a promising strategy to treat hearing loss and vestibular disorders, and Associated adenovirus (AAV) is shown as a good viral vector for inner ear therapy in animal models.
This study aims to study in vitro viral transduction of AAV in human inner ear cells, collected during non-conservative surgeries for vestibular schwannoma.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
- Patient ≥ 18 years old
- Operative indication for a non-conservative resection of vestibular schwannoma, decided by the surgeon in accordance with the patient
- Informed consent obtained
- Patients with a french social protection (AME excluded)
Exclusion Criteria
- Intravestibular or intra-cochlear extension of the tumor
- Pregnant woman
- Patient with administrative control
- Medical contra-indication
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description AAV viral transduction Peroperative collect of inner ear cells Collection of inner ear cells during a non-conservative surgical approach (translabyrinthine or transotic).
- Primary Outcome Measures
Name Time Method AAV transduction in inner ear cells 10 days The transduction will be measured with immunostaining techniques
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
Hôpital de Bicêtre
🇫🇷Le Kremlin-Bicêtre, Ile De France, France
Hôpital Pitié-Salpétrière
🇫🇷Paris, Ile De France, France