Micro-Osteoperforations to Accelerate Maxillary Canine Retraction in Class I Malocclusion

Not Applicable

Completed

• Conditions: Malocclusion, Angle Class I

• Registration Number: NCT07155018
• Lead Sponsor: Can Tho University of Medicine and Pharmacy

Brief Summary

This single-blinded, split-mouth randomized controlled trial investigates whether micro-osteoperforations (MOPs) can accelerate maxillary canine retraction in orthodontic patients requiring bilateral premolar extraction. The study also evaluates postoperative pain levels using the Visual Analog Scale at 1, 3, and 7 days.

Detailed Description

MOPs are a flapless, minimally invasive surgical technique that stimulates bone remodeling and may reduce orthodontic treatment time. In this trial, one side of each patient receives MOPs while the contralateral side serves as control. Canine retraction is performed using miniscrews, power arms, and NiTi coil springs. Outcomes include the rate of canine movement over 16 weeks and pain assessment using VAS.

Study Timeline

• Study Start: 2025-01-01
• Primary Completion: 2025-04-30
• Study Completion: 2025-06-30
• Status Verified: 2025-08
• Study First Submitted: 2025-08-27
• Study First Submitted QC: 2025-08-27
• Last Update Submitted: 2025-08-27
• Study First Posted: 2025-09-04
• Last Update Posted: 2025-09-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Age 16-25 years
• Patients requiring bilateral extraction of maxillary first premolars as part of orthodontic treatment
• Angle Class I molar relationship
• No previous orthodontic treatment

Exclusion Criteria

• History of craniofacial trauma or congenital anomalies
• Systemic or bone-related diseases
• Current smoking
• Use of medications affecting bone metabolism

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Rate of Maxillary Canine Retraction	Baseline, 4, 8, 12, and 16 weeks	Distance of maxillary canine retraction measured on 3D digital dental models using intraoral scanning.

Secondary Outcome Measures

Name	Time	Method
Pain Level (VAS Score)	Day 1, Day 3, Day 7 after intervention	atient-reported pain intensity measured using a 10-cm Visual Analog Scale (VAS), with scores ranging from 0 (no pain) to 10 (worst pain imaginable).

Trial Locations

Locations (1)

Can Tho University Hospital; 🇻🇳 Can Tho, Vietnam