The effect of dairy consumption on metabolic flexibility and glucose metabolism

Completed

• Conditions: preventie/metabole flexibiliteit; na; 10018424

• Registration Number: NL-OMON41078
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

1. Healthy male or postmenopausal female
2. Middle-aged: between 45 and 65 yrs of age
3. BMI >= 25 to <= 30 kg/m2
4. Low-medium dairy consumer (based on VCP, assessed by questionnaire on health and lifestyle)
5. Used to consume 3 main meals a day including breakfast
6. Not involved in intensive sportive activities more than twice a week (e.g. playing football, tennis, running, race-cycling, swimming)
7. Stable weight and no intention to lose weight until completion of the study
8. Able to participate and willing to comply with study procedures and restrictions
9. Signed written informed consent form (ICF)

Exclusion Criteria

1. Diabetes mellitus (based on fasting glucose and HbA1c-values at screening)
2. Clinically relevant abnormalities in blood lipids (total cholesterol > 8 mmol/L, triglycerides > 6 mmol/L, LDL >5,7 mmol/L) at screening
3. Clinically relevant abnormalities in hematology (ao Hb < 8,7 mmol/L ) at screening
4. Clinically relevant abnormalities in markers for liver (ALAT, ASAT) and kidney (creatinine-albumin ratio, urine) damage at screening
5. Positive HIV, HbsAg and/or HepC at screening
6. Not being able to fast overnight (12 hours)
7. Unable to resign from smoking during test day (12h) without symptoms of withdrawal
8. Gastrointestinal disorders or undergone digestive tract surgery (except appendectomy)
9. Intake of nutritional supplements (from screening until the end of the study)
10. Use of medication that would interfere with the study parameters: oral anti-diabetics, insulin, lipid-lowering drugs (from screening until the end of the study) and anti-biotics (from 1 month before screening)
11. Reported slimming or medically prescribed diet
12. Reported vegan, vegetarian or macrobiotic life-style
13. A reported food allergy or sensitivity (e.g. lactose)

Study & Design

• Study Type: Interventional
• Study Design: Not specified