Effects of C16:0 versus C18:0 on HDL metabolism and other cardiometabolic risk markers: A dietary intervention study in healthy normal-weight and overweight subjects - PASTEL (PAlmitic acid STEaric acid and Lipoproteins)

niversiteit Maastricht0 个研究点目标入组 43 人开始时间: 待定最近更新: 2024年4月23日

试验速览

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•- Apparently healthy men and post-menopausal women (post-menopausal for at least one year)
•- BMI * 18.0 and * 30.0 kg/m2
•- Age: 45-70 yrs
•- Signed informed consent

•- Having a medical condition which might impact study measurements
•- Use of over-the-counter and prescribed medication, which may interfere with study measurements
•- Use of oral antibiotics in 40 days or less prior to the start of the study;
•- Use of food supplements or plant-sterol/stanol-enriched foods or supplements in the three months prior to the screening and/or during the study;
•- Reported alcohol consumption * 10 units/week (female) or * 14 units/week (male);
•- Reported intense sporting activities * 10 hours/week;
•- Reported weight loss or gain of 3 kg or more during a period of 2 months prior to screening
•- Regular smokers (at least one cigarette (or equivalent) daily or >7 cigarettes (or equivalent) weekly. Smokers who cannot comfortably restrain from smoking for up to 2 days will also be excluded
•- Reported dietary habits: medically prescribed diet, allergy/intolerance to test products that will be provided during the study
•- Blood donation in the past 3 months
•- Drug abuse
•- Reported participation in another nutritional or biomedical trial 3 months prior to screening
•- Fasting triacylglycerol concentrations at screening: * 4.5 mmol/L
•- Serum lipids: treatment recommended according to the *Multidisciplinaire richtlijn Cardiovasculair risicomanagement*
•- Fasting HbA1c * 48 mmol/mol (or 6.5%)

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