JPRN-UMIN000035103
已完成
未知
High-density Lipoprotein Cholesterol as a Therapeutic Target for Residual Risk in Patients With Acute Coronary Syndrome - High-density Lipoprotein Cholesterol as a Therapeutic Target for Residual Risk in Patients With Acute Coronary Syndrome
Department of Cardiovascular Medicine, Wakayama Medical University0 个研究点目标入组 100 人2018年12月2日
概览
- 阶段
- 未知
- 干预措施
- 未指定
- 疾病 / 适应症
- Patients with acute coronary syndrome with a history of having undergone successful percutaneous coronary intervention
- 发起方
- Department of Cardiovascular Medicine, Wakayama Medical University
- 入组人数
- 100
- 状态
- 已完成
- 最后更新
- 2年前
概览
简要总结
o differences were observed in the baseline LDL-C and HDL-C levels between the two groups. Reduction of LDL-C levels and increase of HDL-C levels were greater in the responder group. On multivariate logistic regression analysis, LDL-C levels (OR: 0.956, 95% CI: 0.921-0.993; p=0.020) and HDL-C levels (OR: 1.143; 95% CI: 1.005-1.300, p=0.041) were independent contributors for plaque stabilization.
研究者
入排标准
入选标准
- 未提供
排除标准
- •1\) Target PCI lesion is graft stenosis or in\-stent restenosis 2\) Patients who had undergone previous PCI for the lesion under evaluation. 3\) Patients who have plaque in a non\-culprit site on the PCI vessel that might call for PCI during the treatment period (non\-culprit lesion is unrestricted) 4\) Patients already receiving lipid lowering agents (HMG\-CoA reductase inhibitors \[statins], fibrates, probucol, nicotinic acid, anion exchange resins, or ezetimib) 5\) Patients with familial hypercholesterolemia 6\) Patients with cardiogenic shock 7\) Patients on cyclosporine therapy 8\) Patients with liver dysfunction (ALT\[GPT] \>\= 100IU), biliary obstruction and/or defective hepatic metabolism: acute hepatitis, acute exacerbation of chronic hepatitis, liver cirrhosis, hepatic carcinoma and/or icterus 9\) Pregnant and possibly pregnant women, lactating women 10\) Patients with renal dysfunction (serum creatinine \>\=2\.0 mg/dL) or on maintenance dialysis 11\) Patients who are judged by the principal or other investigator to be ineligible for enrollment in the study
结局指标
主要结局
未指定
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