NCT00155233Unknown4 期
Interaction Between Nalbuphine and Morphine in Postoperative PCA for Gynecologic Patients
适应症
相关药物
试验速览
- 阶段
- 4 期
- 入组人数
- 200
- 试验地点
- 2
- 主要终点
- analgesic effect
研究概览
简要总结
- Nalbuphine is opioid mu receptor antagonist and kappa receptor agonist
- This study was designed to investigate the interaction between nalbuphine and morphine
详细描述
- Nalbuphine is opioid mu receptor antagonist and kappa receptor agonist
- This study was designed to investigate the interaction between nalbuphine and morphine
- The analgesic effect and opioid-related side effects will be investigated
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Age 18-65 y/o
- •Female patients of ASA physical status I to III
- •Scheduled for elective abdominal hysterectomy, myomectomy, or excision of ovarian tumor
排除标准
- •Patients with a definite diagnosis of chronic pain syndrome, psychiatric disorders, or drug abuse (include opioids, NSAIDs, sedatives, antidepressants)
- •Intraoperative fentanyl use > 3 μg/kg
- •Patients with definite diagnosis of esophageal reflux syndrome
- •Use of sedatives, antiemetics, or antipruritics within 24 hours before operation
- •Surgery > 4 hours or laparoscopy surgery
结局指标
主要结局
analgesic effect
次要结局
- incidence of opioid-related side effects
研究者
研究点 (2)
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