Withdrawing off-label antipsychotics in people with intellectual disabilities: why does it fail?
Recruiting
- Conditions
- Antipsychotics, intellectual disabilitiesAntipsychotica, verstandelijke beperking
- Registration Number
- NL-OMON21687
- Lead Sponsor
- Erasmus MC
- Brief Summary
1. Beumer S, Festen, D. Reduction or discontinuation of antipsychotics for challenging behavior in adults with intellectual disability: why does it fail?” Lancet Psychiatry. Vol 4, No3 e2,March 2017
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 122
Inclusion Criteria
Adults with ID (IQ < 70), using off-label antipsychotics (pipamperone or risperidone) since > 1 year for behavioral problems.
Participants are living (=>ZZP4) in three participating ID care organizations of the HA-ID consort.
Exclusion Criteria
Diagnosis of psychosis, dementia, schizophrenia, psychotic disorder NOS, delirium, failed attempt to withdraw AP < 6 months ago, usage of >1 AP drug
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The percentage of participants completing the protocol in the discontinuation group” (gradual decline of AP dose) compared to the control group” (continuing AP dose).
- Secondary Outcome Measures
Name Time Method Behavior<br /><br>Psychiatric disorders<br /><br>Sleep problems<br /><br>Side effects / withdrawal symptoms