RADAR Trial: Testing the effects of reducing and discontinuing antipsychotic medication in people with long-term schizophrenia and similar conditions
- Conditions
- SchizophreniaMental and Behavioural Disorders
- Registration Number
- ISRCTN90298520
- Lead Sponsor
- niversity College London
- Brief Summary
2019 Protocol article in https://pubmed.ncbi.nlm.nih.gov/31780589/ protocol (added 27/10/2020) 2023 Results article in https://pubmed.ncbi.nlm.nih.gov/37778356/ (added 02/10/2023)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 253
1. Aged over 18 years
2. A clinical and/or ICD10 diagnosis of schizophrenia, schizoaffective disorder, delusional disorder or other non-affective psychosis
3. More than one previous episode of relapse or psychotic exacerbation, or a single episode lasting more than one year
4. Taking antipsychotic medication
1. Participant lacks capacity to consent to the trial
2. Participant has insufficient command of spoken English to understand trial procedures
3. Participant subject to a Community Treatment Order (CTO) that includes a requirement to take antipsychotic medication
4. Clinician considers there will be a serious risk of harm to self or others
5. Participant has been admitted to hospital or had treatment from the Home Treatment or Crisis Team within the last month
6. Females who have a confirmed pregnancy
7. Females who are breast-feeding
8. Involvement in another IMP trial
9. No contraindications to continuing on antipsychotic medication
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Social functioning is measured by the Social Functioning Scale at baseline, 6, 12 and 24 months<br><br>Added 14/09/2022:<br>Also measured between 48-84 months from randomisation into the original trial
- Secondary Outcome Measures
Name Time Method