Managing adolescent first episode psychosis: a feasibility study

Not Applicable

Completed

• Conditions: Specialty: Mental Health, Primary sub-specialty: Psychosis; UKCRC code/ Disease: Mental Health/ Organic, including symptomatic, mental disorders; Mental and Behavioural Disorders; First episode psychosis

• Registration Number: ISRCTN80567433
• Lead Sponsor: Greater Manchester West Mental Health NHS Foundation Trust

Brief Summary

2019 protocol in https://www.ncbi.nlm.nih.gov/pubmed/31272477 (added 08/07/2019) 2020 results in https://pubmed.ncbi.nlm.nih.gov/32649925/ (added 13/07/2020) 2021 results in https://pubmed.ncbi.nlm.nih.gov/33496261/ (added 27/01/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-02-27
• Study Completion: 2019-06-30
• Last Update Posted: 8 February 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 61

Inclusion Criteria

1. Aged 14-18 (to ensure adolescent status)
2. In contact with Early Intervention Services/Child and Adolescent Mental Health Services (to ensure appropriate safety considerations can be implemented)
3. Competent to provide written, informed consent, with additional parental consent for those aged < 16 (for ethical considerations).
4. Either meet ICD-10 criteria for schizophrenia, schizoaffective disorder or delusional disorder or meet entry criteria for an Early Intervention for Psychosis service (operationally defined using PANSS) to allow for diagnostic uncertainty in early phases of psychosis
5. Within 1 year of onset of psychosis (to ensure first episode status)
6. Score 4+ on Positive and Negative Syndrome Scale (PANSS) delusions or hallucinations [for a minimum duration of seven consecutive days] (to ensure current psychosis)
7. Help-seeking (for ethical considerations)

Exclusion Criteria

1. A primary diagnosis of alcohol/substance dependence *
2. A diagnosis of moderate or severe learning disability *
3. A diagnosis of ICD-10 organic psychosis *
4. Score 5+ on PANSS conceptual disorganisation / disorganised speech (since majority of participants will be randomised to a talking therapy, we require capacity to answer questions in an interview situation and engage in a conversation)
5. Non-English speaking (since majority of participants will be randomised to a talking therapy)
6. Received APs or structured PI within the last 3 months (to ensure treatment naivety)
7. Immediate risk to self or others (to ensure appropriate safety considerations can be addressed)

* These exclusions are to ensure that the participant population are representative of young people with a primary problem of first episode psychosis

Study & Design

• Study Type: Interventional
• Study Design: Not specified