Glucose Metabolism in Different PCOS Phenotypes

Completed

• Conditions: Liver Fat; Glucose Intolerance; Glucose Metabolism Disorders; Polycystic Ovary Syndrome
• Interventions: Diagnostic Test: Oral glucose tolerance test (OGTT); Other: 1H-magnetic resonance spectroscopy

• Registration Number: NCT03204461
• Lead Sponsor: Medical University of Vienna

Brief Summary

In the present study glucose metabolism and ectopic lipids in the liver, heart and muscle were investigated in women with the polycystic ovary syndrome (PCOS) and in healthy control subjects.

Detailed Description

In detail an oral glucose tolerance test (OGTT) was conducted in women with the PCOS defined by the Rotterdam and the NIH-criteria, as well as in healthy control subjects. In addition 1H-magnetic resonance spectroscopy and Imaging was used for the assessment of the ectopic lipid content in the liver, heart and skeletal muscle. The aim of the present study was to compare the glucose metabolism and the ectopic lipid conent in the liver, heart and muscle between women with the PCOS defined by the NIH-criteria, Rotterdam-criteria and healthy control subjects.

Study Timeline

• Study Start: 2012-12-03
• Primary Completion: 2015-07-09
• Study Completion: 2015-07-30
• Status Verified: 2017-06
• Study First Submitted: 2017-06-26
• Study First Submitted QC: 2017-06-27
• Last Update Submitted: 2017-06-27
• Study First Posted: 2017-07-02
• Last Update Posted: 2017-07-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 73

Inclusion Criteria

• Women with the polycystic ovary Syndrome defined according to the Rotterdam and the NIH-criteria
• healthy control subjects

Exclusion Criteria

• BMI>=40kg/m²
• Diagnosis of Diabetes in the PCOS-Group
• Diagnosis of Prediabetes or Diabetes in the control group

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
PCOS-NIH	Oral glucose tolerance test (OGTT)	-
PCOS-Rotterdam	1H-magnetic resonance spectroscopy	-
PCOS-Rotterdam	Oral glucose tolerance test (OGTT)	-
PCOS-NIH	1H-magnetic resonance spectroscopy	-
Controls	Oral glucose tolerance test (OGTT)	-
Controls	1H-magnetic resonance spectroscopy	-

Primary Outcome Measures

Name	Time	Method
Comparison of glucose metabolism between PCOS women and healthy control subjects, using data of the OGTT.	Up to 4 weeks	In the present study the Glucose metabolism in PCOS women and control subjects was assessed with an OGTT. Therefore the dynamic levels of glucose, insulin and C-peptide were assessed during an extended OGTT for the calculation of Insulin resistance and beta-cell function. In addition an 1H-magnetic resonance spectroscopy was done for the assessment of the ectopic lipid content in the liver, heart and the skeletal muscle.

Trial Locations

Locations (1)

Medical University of Vienna; 🇦🇹 Vienna, Austria