Associatons of PCOS Phenotypes With Ectopic Lipids, Adipocytokines and Parameters of Insulin Resistance
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 73
- 试验地点
- 1
- 主要终点
- Comparison of glucose metabolism between PCOS women and healthy control subjects, using data of the OGTT.
研究概览
简要总结
In the present study glucose metabolism and ectopic lipids in the liver, heart and muscle were investigated in women with the polycystic ovary syndrome (PCOS) and in healthy control subjects.
详细描述
In detail an oral glucose tolerance test (OGTT) was conducted in women with the PCOS defined by the Rotterdam and the NIH-criteria, as well as in healthy control subjects. In addition 1H-magnetic resonance spectroscopy and Imaging was used for the assessment of the ectopic lipid content in the liver, heart and skeletal muscle. The aim of the present study was to compare the glucose metabolism and the ectopic lipid conent in the liver, heart and muscle between women with the PCOS defined by the NIH-criteria, Rotterdam-criteria and healthy control subjects.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Women with the polycystic ovary Syndrome defined according to the Rotterdam and the NIH-criteria
- •healthy control subjects
排除标准
- •BMI>=40kg/m²
- •Diagnosis of Diabetes in the PCOS-Group
- •Diagnosis of Prediabetes or Diabetes in the control group
结局指标
主要结局
Comparison of glucose metabolism between PCOS women and healthy control subjects, using data of the OGTT.
时间窗: Up to 4 weeks
In the present study the Glucose metabolism in PCOS women and control subjects was assessed with an OGTT. Therefore the dynamic levels of glucose, insulin and C-peptide were assessed during an extended OGTT for the calculation of Insulin resistance and beta-cell function. In addition an 1H-magnetic resonance spectroscopy was done for the assessment of the ectopic lipid content in the liver, heart and the skeletal muscle.
次要结局
未报告次要终点
研究者
Alexandra Kautzky-Willer
Univ.Prof.Dr.
Medical University of Vienna