Passive Leg Raise Induced Stroke Volume Changes in Elderly Prior to Elective Surgery Measured by LiDCOplusTM

Not Applicable

Completed

• Conditions: Cardiovascular System; Fluid Therapy; Stroke Volume
• Interventions: Other: Passive leg raise

• Registration Number: NCT02977390
• Lead Sponsor: Karolinska Institutet

Brief Summary

This is a pilot study to investigate whether patients at advanced age are fluid responders via a reversible fluid challenge, the passive leg raise test. This will be measured with a non-invasive cardiac output monitor, the LiDCO (LiDCO Hemodynamic monitoring) .

Detailed Description

The intervention is as simple as a passive leg raise with measurement of effect on Stroke volume.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2013-10
• Primary Completion: 2015-01
• Study Completion: 2015-01
• Status Verified: 2016-11
• Study First Submitted: 2016-11-22
• Study First Submitted QC: 2016-11-29
• Study First Posted: 2016-11-30
• Last Update Submitted: 2016-11-30
• Last Update Posted: 2016-12-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• patients ≥80 years of age, undergoing elective urologic surgical procedure

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Exclusion Criteria

• age <80 years, severe aortic insufficiency, first case of the day on the operation program, unavailability of research personnel and contraindication to Lithium.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Passive Leg Raise (PLR)	Passive leg raise	The patient is placed in a 45 degree recumbent position. Stroke volume is measured in ml. Intervention:The patient is placed horizontal and the legs are passively raised to 45 degrees. Measurement:The effect of the PLR on Stroke Volume is measured. Thereafter the patient is repositioned to the initial position and Stroke Volume is measured again.

Primary Outcome Measures

Name	Time	Method
Assess passive leg raise responsiveness in spontaneously breathing aged patients.	Within 1 minute of the intervention	Stroke volume changes in ml and as per cent change compared to baseline

Secondary Outcome Measures

Name	Time	Method
Investigate whether there is an association between a positive response to passive leg raise on stroke volume and post spinal anesthesia.	30 minutes	Post spinal bloodpressure per cent change or 30 mmHg decrease

Trial Locations

Locations (1)

Karolinska University Hospital; 🇸🇪 Huddinge, Sweden