The Effects of Oxidative Stress and Vitamin E on the Development and Progression of Burning Mouth Syndrome

Not Applicable

Recruiting

• Conditions: Diseases of the digestive system

• Registration Number: KCT0005224
• Lead Sponsor: Ajou University Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 18 August 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 30

Inclusion Criteria

burning mouth syndrome patients who have sustained orofacial pain more than 3 months without any substantial abnormalities in the oral cavity
- post-menopausal females
- participants who agreed to enroll this clinical trial

Exclusion Criteria

-Participants who have hypersensitivity on Grandferol 400IU
-Hypertension patients
-Participants who have history of asthma, rash, uticaria
-Participants taking vitamin A or vitamin K or having thrombolism
-Participants taking oral anticoagulant
-Participants taking Orlistat or mineral oil
-Hyperproteinemina, hypercholesterolemia or pancreatitis patients who had abnormal lipid metabolism
-Participants with lipid overload
-Participants with malignant tumor, history of radiation therapy or radiation isotope therapy in head and neck area
-Participants taking steroid, immune suppressant, or cytotoxic drug
-Participants with uncontrolled diabetes or thyroid disorder
-Participants with coagulation problem
-Participants with liver diseases
-Participants who are unable to communicate

Study & Design

• Study Type: Interventional Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
extents of oxidative stress in saliva and serum (8-hydroxy-2’-deoxyguanosine (8-OHdG), total antioxidant capacity (TAC), uric acid)

Secondary Outcome Measures

Name	Time	Method
degree of pain (Visual Analog Scale, Oral Health Impact Profile-49, McGuill questionnare)