Effect of Vitamin E on Oxidative Stress Level in Blood, Synovial Fluid, and Synovial Tissue in Severe Knee Osteoarthritis: A Randomized Controlled Study

Not Applicable

Completed

• Conditions: All patients had severe knee osteoarthritis requiring total knee arthroplasty in 2 monthsAll patients must be fit for surgery and passed preoperative medical check up; knee osteoarthritis; oxidative stress; antioxidant; anti- inflammation; vitamin E

• Registration Number: TCTR20160828001
• Lead Sponsor: Ratchadaphiseksomphot Endowment Fund

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2012-05-31
• Study Start: 2016-08-28
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 72

Inclusion Criteria

≥18 years of age
Clinically diagnosed with knee OA according to the criteria of the American College of Rheumatology
Radiographically diagnosed with severe knee OA (grade 3â€4) as defined by the Kellgrenâ€Lawrence classification [17]
Scheduled for total knee arthroplasty (TKA) within 2 months

Exclusion Criteria

Established diagnosis of a bleeding disorder
Currently used vitamin E-containing drugs or dietary supplements
On anticoagulants, or antiplatelet therapy
Had a vitamin E allergy.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
evel of oxidative stress and antioxidant Blood were test before atart intervention and 2 month after intervention; The synovial fluid was obt Level of oxidative stress and antioxidant were measured in blood and synovial fluid (knee)

Secondary Outcome Measures

Name	Time	Method
Knee society score, WOMAC score, adverse affect of vitamin E Before intervention and 2 month after intervention Interview patient by researcher