Hyaluronic Acid Effect on Xenogenic Bone Healing

Not Applicable

Completed

• Conditions: Tooth Loss; Bone Resorption

• Registration Number: NCT04377256
• Lead Sponsor: Saint-Joseph University

Brief Summary

The aim of this study is to test the hyaluronic acid hydrogel impact on the healing acceleration of xenogenic bone substitutes used in ridge preservation.

Following tooth extraction, bone particles are mixed with the hyaluronic acid gel and grafted in the tooth socket. at the implant placement phase, a cone beam computer assisted tomography file is recorded in order to compare it with the baseline and a biopsy to evaluate the histological consequences.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-05-01
• Study First Submitted: 2020-05-03
• Study First Submitted QC: 2020-05-03
• Study First Posted: 2020-05-06
• Primary Completion: 2021-01-10
• Study Completion: 2021-05-10
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-31
• Last Update Posted: 2025-04-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 7

Inclusion Criteria

• Patients in need of tooth extraction and willing to receive dental implants in the extraction site
• Presence of two mono radicular teeth in need of extraction

Exclusion Criteria

• Patients with systemic diseases
• Patients under 8 years and above 60 years.
• Presence of endodontic or periodontal lesion in the extraction sites

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Radiological assessement of the boe resorption	4 months	the baseline if the CBCT is compared to the 4 months post-op to assess the bone resorption
Histomorphometric analysis	4 months	During implant placement, a bone biopsy is harvested and stained with different colorants to assess microscopically the biological healing

Trial Locations

Locations (2)

Saint-Joseph university; 🇱🇧 Beirut, Lebanon

Universte Saint Joseph-Beyrouth; 🇱🇧 Beirut, Lebanon