the Effect of Hyaluronic Acid on a Prefabricated CAD-CAM Bone Blocks for Ridge Augmentation
- Conditions
- Atrophy of Edentulous Alveolar Ridge
- Interventions
- Procedure: prefabricated CAD-CAM allogeneic bone block hydrated using hyaluronic acidProcedure: prefabricated CAD-CAM allogeneic bone block sterilized hydrated using saline solution
- Registration Number
- NCT06395818
- Lead Sponsor
- Tanta University
- Brief Summary
Each patient will receive 2 prefabricated CAD-CAM allogeneic bone blocks sterilized with gamma rays with different rehydration methods.
Side I: prefabricated CAD-CAM allogeneic bone block sterilized with gamma rays hydrated using hyaluronic acid \* Side II: prefabricated CAD-CAM allogeneic bone block sterilized with gamma rays hydrated using saline solution Both blocks are fixed with osteosynthesis screws, covered with non resorbable membranes\*\* The membranes will be removed after 6 months, dental implants will be placed and core biopsy will be collected from the site of the implant placement for histologic evaluation
- Detailed Description
10 patients will be included in this study with bilateral atrophic posterior mandible for split mouth research
. group I: prefabricated CAD-CAM allogeneic bone block sterilized with gamma rays hydrated using hyaluronic acid group II: prefabricated CAD-CAM allogeneic bone block sterilized with gamma rays hydrated using saline solution under LA mucoperiosteal flap will be elevated to expose the atrophic ridge then the prefabricated CAD-CAM allogenic block either mixed with hyaluronic acid (group I) or saline (group II) will be fixed in its position with titanium miniscrews , The block was coated with a nonporous d-PTFE membrane then closure of flap with nylon second stage: 6 months later exposure of alveolar ridge core biopsy was taken for histological study then insertion of titanium implants.
the aim of the study is to investigate the effect of hyaluronic acid on a prefabricated CAD- CAM bone blocks for ridge augmentation radiographically and histologically.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 10
Not provided
- Systemic diseases that affect host healing responses.
- Heavy smoking.
- Poor oral hygiene.
- Traumatic occlusion, sever para-functional habits (ex. bruxism, clenching,)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description prefabricated CAD-CAM allogeneic bone block hydrated using hyaluronic acid prefabricated CAD-CAM allogeneic bone block hydrated using hyaluronic acid mucoperiosteal flap will be elevated to expose the atrophic ridge then the prefabricated CAD-CAM allogenic block will be fixed in its position with titanium miniscrews , autogenous bone graft will be taken from the ramus mixed with hyaluronic acid and cover the allogenic block prefabricated CAD-CAM allogeneic bone block sterilized hydrated using saline solution prefabricated CAD-CAM allogeneic bone block sterilized hydrated using saline solution mucoperiosteal flap will be elevated to expose the atrophic ridge then the prefabricated CAD-CAM allogenic block will be fixed in its position with titanium miniscrews , autogenous bone graft will be taken from the ramus mixed with saline and cover the allogenic block
- Primary Outcome Measures
Name Time Method measurement the width and the height of the alveolar ridge 6 months using CBCT the width and the height will be measured with measuring tools in milimeter (mm)
the amount of new bone formation 6 months core biopsy will be underwent histomorphometric analysis to determine the percentage of new bone formation (%)
- Secondary Outcome Measures
Name Time Method the sucess of dental implants 12 months usingCBCT to determine the amount of marginal bone loss in (mm)
Trial Locations
- Locations (1)
Faculty of Dentistry, Tanta University
🇪🇬Tanta, Egypt