Effect of Amino Acid Addition to a Drink on the Appearance of Ingested Water in Body Fluids
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Time at which 50% of drink was absorbed (t1/2)
研究概览
简要总结
To determine the effects of a moderate amount of amino acids on the rate of water absorption and availability as a precursor fluid for sweat. Young and healthy (male or female) volunteers will take part in three experimental trials. In each trial, volunteers will be given one of two commercially available sports drinks or a commercially available sport drink with added amino acids in a double-blinded, randomised, crossover design. Each drink will be a single 600 mL bolus. All beverages will be labelled with deuterium (D2O). Trials will be compared for temporal accumulation of deuterium in plasma over the course of 60 minutes. Whole blood measurements of haemoglobin and haematocrit will also be made and plasma volume changes calculated. It is hypothesised that the amino acid trial will increase the rate of fluid absorption.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
盲法说明
Double-blind
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Generally fit and healthy (determined by health screen questionnaire)
- •Recreationally active (minimum 3 hours of physical activity per week including walking)
排除标准
- •Any cardiovascular, gastrointestinal, renal or acute/chronic health conditions that may influence the outcomes
- •Smoking (including vaping)
- •BMI of greater than 30 (combined with a body fat percentage greater than 20%) or BMI lower than 17.5
结局指标
主要结局
Time at which 50% of drink was absorbed (t1/2)
时间窗: 60 minutes
Determined from D2O values in venous blood samples collected before and after drink ingestion
Maximum absorption rate of drink
时间窗: 60 minutes
Determined from D2O values in venous blood samples collected before and after drink ingestion
Time at which drink absorption rate returned to 0 (t2)
时间窗: 60 minutes
Determined from D2O values in venous blood samples collected before and after drink ingestion
Area under the curve for D2O
时间窗: 60 minutes
Determined from D2O values in venous blood samples collected before and after drink ingestion
Time at which drink absorption rate was maximum (t1)
时间窗: 60 minutes
Determined from D2O values in venous blood samples collected before and after drink ingestion
次要结局
- Urinary specific gravity(60 minutes)
- Plasma volume(60 minutes)
- Plasma osmolality(60 minutes)
- Plasma lactate concentration(60 minutes)
- Plasma creatinine concentration(60 minutes)
- Plasma amino acid concentration(60 minutes)
- Plasma glucose concentration(60 minutes)
研究者
Lewis James
Senior Lecturer in Nutrition
Loughborough University