Damage and Renal Clearance of Glycocalyx in Cardiac Surgery

Completed

• Conditions: Glycocalyx; Cardio-Renal Syndrome

• Registration Number: NCT04332952
• Lead Sponsor: Miguel Ayala León

Brief Summary

The glycocalyx is a component of the vascular endothelium that currently plays a relevant role in the modified Starling theory.

The manipulation of the heart during cardiac surgery stimulates the release of the natriuretic atrial peptide, which causes endothelial wear in patients undergoing extracorporeal circulation. Dilation of the atrium produces natriuretic atrial peptide, which reduces plasma volume by increasing renal excretion and vascular permeability. The atrial peptide degrades the surface of the coronary endothelium, causing loss of the side cam protein nucleus. This study investigates the relationship between clamping time in cardiac surgery and the clearance of endothelial inflammation markers.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-08-01
• Primary Completion: 2017-10-01
• Study Completion: 2017-12-31
• Status Verified: 2020-04
• Study First Submitted: 2020-04-01
• Study First Submitted QC: 2020-04-01
• Study First Posted: 2020-04-03
• Last Update Submitted: 2020-04-07
• Last Update Posted: 2020-04-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

• Over 18 years of age
• Patients who underwent cardiac surgery for a single valve change or replacement

Exclusion Criteria

• Stage 3 renal failure patients
• Patients with a previous diagnosis of hematological malignancy
• Patients undergoing pulmonary valve change surgery.
• Patients undergoing Bentall and Bono surgery.
• Patients Undergoing Coronary Artery Bypass Surgery

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Aortic clamping time	2 hours	Duration of aortic clamping time in minutes
Extracorporeal circulation time	2 hours	Duration of Extracorporeal Circulation in minutes
Sydecan -1 levels in urine before surgery	30 minutes	Quantity of Sydecan -1 in urine before surgery
Hyaluronic acid levels in blood before surgery	30 minutes	Quantity of hyaluronic acid in blood before surgery
Hyaluronic acid levels in urine before surgery	30 minutes	Quantity of hyaluronic acid in urine before surgery
Hyaluronic acid levels in urine after surgery	30 minutes	Quantity of hyaluronic acid in urine before surgery
Hyaluronic acid levels in blood after surgery	30 minutes	Quantity of hyaluronic acid in blood after surgery
Sydecan -1 levels in blood before surgery	30 minutes	Quantity of Sydecan -1 in blood before surgery
Sydecan -1 levels in blood after surgery	30 minutes	Quantity of Sydecan -1 in blood after surgery
Sydecan -1 levels in urine after surgery	30 minutes	Quantity of Sydecan -1 in urine after surgery

Trial Locations

Locations (1)

Hospital Beneficencia Española de Puebla; 🇲🇽 Puebla, Mexico