The endothelial glycocalyx in premature cardiovascular disease

• Conditions: coronary artery disease; coronary atherosclerosis; 10011082; 10003216

• Registration Number: NL-OMON33709
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 420

Inclusion Criteria

Men with a first cardiovascular event under de age of 41, woman under the age of 46. Furthermore a positive family history for CVD

Exclusion Criteria

A positive history for hypertension, diabetes mellitus or other malignant or chronic inflammatory disease.
Pregnancy or lactating women

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Assessment of the glycocalyx by Sidestream Dark Field Imaging (SDF) before and<br /><br>after NTG</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Assesment of risk factors through blood samples (diabetes/cholesterol levels)<br /><br>Assesment of PWV</p><br>