Glycocalyx measurements in premature atherosclerosis

Completed

• Conditions: Atherosclerosis; vascular abnormalities; 10011082; 10007510; 10003216

• Registration Number: NL-OMON30991
• Lead Sponsor: Academisch Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

Cases:
- a cardiac, cerebral or peripheral vascular disease before the age of 40
- a positive family history for cardiovascular disease, defined as a first degree family member with a cardiovascular event before the age of 55 for men and 60 for women. Furthermore, they should be between the age of 35 and 55 years old.
Controls:
-Controls will be defined as healthy in case they have no cardiovascular history, such as no cardiac, cerebrovascular or peripheral artery disease and no complaints of angina, claudication or TIA and no family history for cardiovascular disease. Furthermore, they should be between the age of 35 and 55 years old.

Exclusion Criteria

Cases:
- a positive history for hypertension or diabetes mellitus
- pregnancy or lactating women
- subjects below the age of 18
- unable to give informed consent
Controls:
Diseases mentioned at the inclusioncriteria.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Changes in the volume of the intravascular glycocalyx between the different<br /><br>subjectgroups.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable.</p><br>