A study of the local anaesthetic lidocaine and the antibiotic doxycycline to help protect the blood vessel lining in patients undergoing heart surgery.

Phase 4

Recruiting

• Conditions: Ischaemic Heart Disease; Valvular Heart Disease; Aortic Disease; Anaesthesiology - Anaesthetics; Cardiovascular - Coronary heart disease; Cardiovascular - Diseases of the vasculature and circulation including the lymphatic system; Cardiovascular - Other cardiovascular diseases

• Registration Number: ACTRN12619000621112
• Lead Sponsor: Hearty and Lung Institute of Western Australia

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-04-26
• Last Update Posted: 13 September 2021

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

All adult patients with capacity to consent undergoing operations requiring cardiopulmonary bypass.

Exclusion Criteria

Unable to consent/ refusal.
Hypersensitivity to study drugs.
Operations not requiring cardiopulmonary bypass.
Known or suspected liver disease
Alcoholism

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in syndecan-1 (Biochemical marker of endothelial glycocalyx injury).<br>Expressed as a fold increase of baseline (pre-induction) level.<br>Assessed by serial serum assays. <br>[Serial measurements,<br>1. pre induction through invasive monitoring line.<br>2. after protamine administration (heparin reversal after end of cardiopulmonary bypass)<br>3. admission to ICU<br>4. 6 hours post operatively. <br>5. First post operative morning<br><br>(Prior work has a peak at 6 hours with diminishing levels observed by the morning of day 1 post op)]