The relationship between the endothelial glycocalyx and peritoneal transport in peritoneal dialysis patients

Completed

• Conditions: peritoneale dialyse; peritoneal dialysis; peritoneal transport; 10038430

• Registration Number: NL-OMON41139
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

clinically stable chronic peritoneal dialysis patients

Exclusion Criteria

clinically unstable patients
during acute peritonitis
suspicion of encapsulating peritoneal sclerosis

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The following parameters will be investigated:<br /><br><br /><br>1. The status of the microvascular glycocalyx by sublingual measurement with<br /><br>orthogonal polarization spectroscopy (SDF)<br /><br>2. Glycocalyx constituents, like hyaluronan in plasma and peritoneal effluent<br /><br>3. Biomakers in peritoneal effluent<br /><br>4. Residual renal function<br /><br>5. Blood pressure<br /><br>6. Standard peritoneal permeability analysis<br /><br><br /><br>Note: 4,5 and 6 are part of normal clinical patient care</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable</p><br>