on-invasive glycocalyx measurements in premature atherosclerosis
- Conditions
- 1000321610011082Atherosclerosisvascular abnormalities10007510
- Registration Number
- NL-OMON33763
- Lead Sponsor
- niversiteit Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 40
Cases: - a cardiac, cerebral or peripheral vascular disease before the age of 40 - a positive family history for cardiovascular disease, defined as a first degree family member with a cardiovascular event before the age of 55 for men and 60 for women. Furthermore, they should be between the age of 36 and 56 years old. Controls: -Controls will be defined as healthy in case they have no cardiovascular history, such as no cardiac, cerebrovascular or peripheral artery disease and no complaints of angina, claudication or TIA and no family history for cardiovascular disease. Furthermore, they should be between the age of 36 and 56 years old.
Cases: - a positive history for hypertension or diabetes mellitus - pregnancy or lactating women - subjects below the age of 18 - unable to give informed consent Controls: Diseases mentioned at the inclusioncriteria.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Change in glycocalyx volume, before and after sublingual nitroglycerine<br /><br>administration between the different study groups</p><br>
- Secondary Outcome Measures
Name Time Method <p>To compair the glycocalyx volume of the different study groups we measure this<br /><br>year, with last year's measurements.</p><br>