Glycocalyx in cerebral small vessel disease

Completed

Conditions: cerebral small vessel disease
10007963
10047066

Registration Number: NL-OMON36152

Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 60

Inclusion Criteria

patients: first-ever lacunar stroke in the last 2 years, age 50-85 years
healthy controls: age 50-85 years, without major co-mobidity

Exclusion Criteria

patients: carotid stenosis, cardioembolic source, diabetes, coronary heart disease, major co-morbidity
healthy controls: hypertension, diabetes, cardiovascular disease (TIA/stroke/coronary heart disease), use of cardiovascular medicine, silent signs of cSVD on (former) brain MRI

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Registration of baseline characteristics (age, gender, weight, length,<br /><br>medication, cardiovascular risk profile, brain MRI)<br /><br>Venous blood sampling for measuring of glucose, cholesterol, kreatinin, and CRP.<br /><br>Measurement of the sublingual glycocalyx, non-invasively using sidestream dark<br /><br>field imaging.<br /><br><br /><br>We will compare glycocalyx thickness between patients and controls, and between<br /><br>patients with and without silent lesions.<br /><br>Predictors of glycocalyx thickness will be analysed using regression analyses.</p><br>

Secondary Outcome Measures