Changes in sugar content of the brain during narcosis

Recruiting

Conditions: cerebral glucose metabolism
polyol pathway
Postoperative cognitive dysfunction (POCD)
hyperglycemia
delirium
neurocognitive
Cerebrospinal fluid (CSF)
sorbitol
fructose
thoracic aortic surgery

Registration Number: NL-OMON20502

Lead Sponsor: Sponsor: Amsterdam UMC. location AMC, Department of Anesthesiology

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 16

Inclusion Criteria

Patients undergoing elective thoracic aortic surgery without pre-existing brain disease and without diabetes mellitus who are able and willing to participate in the study and can provide written informed consent. Patients must be 18 years or older.

Exclusion Criteria

Patients undergoing elective thoracic aortic surgery with pre-existing brain disease and/or diabetes mellitus. Patients who are unable to understand or fill-in questionnaires in Dutch will also be excluded from the study.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The main outcome measures per aim are:<br /><br>- The changes in cerebral glucose metabolism in the perioperative period as measured by the difference in CSF/plasma ratio* of glucose at different points in time<br /><br>- The increase in cerebral sorbitol and fructose concentrations in the perioperative pe-riod as measured by the difference in CSF/plasma ratio of sorbitol and fructose at dif-ferent points in time<br /><br /><br><br>*The CSF/plasma glucose ratio is used because of our hypothesis that an immediate reduc-tion in cerebral hexokinase activity will cause an increase in cerebral glucose and therefore an increase in the CSF/plasma glucose ratio.

Secondary Outcome Measures

Name	Time	Method
- Correlation of perioperative plasma glucose levels with CSF glucose levels<br /><br>- Correlation between the Montreal Cognitive Assessment score and CSF sorbitol and fructose levels<br /><br>- Cortisol plasma levels in the perioperative period for the given points in time<br /><br>- C-reactive protein (CRP) plasma levels in the perioperative period for the given points in time<br /><br>- Demographics (age, gender, ethnicity)<br /><br>- Length<br /><br>- Height<br /><br>- BMI<br /><br>- Medical history<br /><br>- Medication use<br /><br>- ASA classification