eurometabolites and functional brain connectivity in experienced ayahuasca users of the Santo Daime Church before and after drinking the psychedelic ayahuasca brew: an observational study

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 20

Inclusion Criteria

* Must be a member of the Santo Daime church, who volunteers to participate in
the research project.
* Must be older than 18 years of age.

Exclusion Criteria

* Medical devices and implants containing metal (e.g. pacemakers, copper birth
control spirals, permanent jewelry, aneurysm clips, hearing aids)
* Permanent make-up and other large tattoos
* Pregnancy or lactation.
* Use of (medicinal) substances in the past 24 hours which can interact with
MAO inhibitors, including further MAO inhibitors (tranylcypromine, Parnate,
Nardil, Aurorix, etc), all sympathomimetics (including amphetamine, cocaine,
methylphenidate, ephedrine, metaraminol, certain asthma agents), certain
medicines for cough, cold, hay fever, and allergies that are available without
a prescription, such as Otrivin and dextromethorphan-containing agents (Dampo,
VapoTab *Vicks*, Darolan and others) and antihistamines, diet medication (such
as Ponderal), all antidepressants including SSRIs (citalopram, sertraline, etc)
and trycyclic antidepresssents (clomipramine, etc), certain anti-asthma
medications such as Berotec, Bricanyl, Ventolin, Salbutamol, Terbutaline,
Pulmadil, or Serevent, blood pressure medication (beta blockers, methyldopa,
thiazide diuretics, calcium antagonists, and ace inhibitors), antimicrobials or
antibiotics, narcotic analgesices (including pethidine), or other substances
like St. John*s wort, lithium, alprazolam, buspirone, L-tryptophan, L-DOPA,
disulfiram, hydralazine (such as Apresoline), and carbamazepine (such as
Tegretol).
* Use of Prozac in the past 2 weeks.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is the drug induced change in brain activity and<br /><br>neurometabolite concentration when comparing ayahuasca to baseline. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Additionally, the change in subjective state and cognitive flexibility will be<br /><br>assessed and correlated with the neurological effects. Lastly, we will evaluate<br /><br>the modulatory effects of the ceremonial setting on these changes through a<br /><br>controlled music paradigm.</p><br>