Microvasculopathy in Cerebral Small Vessel Disease

Conditions: Cerebral small vessel disease / Ischemic stroke
10007963

Registration Number: NL-OMON30895

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 16

Inclusion Criteria

Inclusion criteria cerebral large vessel disease group
TIA or stroke patients with one of the following:
-clinically demonstrated loss of sensibility
-clinically demonstrated loss of motor function;and including one or more of the following:
-hemianopsia
-aphasia
-neglect;and a carotid stenosis of more than 70% at the ipsilateral side.

Inclusion criteria cerebral small vessel disease group
Patients with a clinically established lacunar syndrome (see appendix A) and lacunar infarcts and/or leukoaraiosis on CT.

Exclusion Criteria

Exclusion criteria for both groups are:
-Age of less than 18 years
-Incapacitated subjects
-A Modified Rankin Scale (MRS) >3
-Diabetes Mellitus type I and II
-Smoking
-Iodine allergy
-Hyperthyroidism

Exclusion criteria cerebral large vessel disease group
-Lacunar infarcts and/or leukoaraiosis on CT
-Indication of a cardiac source of intracranial embolism;Exclusion criteria cerebral small vessel disease group
-Carotid stenosis of more than 30%
-Intermittent claudication
-Angina pectoris
-Myocardial infarction
-Radiologically demonstrated cortical infarction

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study endpoint is the difference in endothelial microvascular<br /><br>glycocalyx thickness between patients with cerebral small vessel disease and<br /><br>patients with large vessel atherosclerosis.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The presence of blood parameters related to glycocalyx destruction in patients<br /><br>with cerebral small vessel disease.<br /><br>The presence of microalbuminuria in both research groups.<br /><br>The presence of pathological changes in microvessels found in skin biopsy.</p><br>