Microvascular lesions in the brain: a new perspective on cognitive impairment in type 2 diabetes

Withdrawn

• Conditions: 10014623; type 2 diabetes mellitus; 10012653; 10047075

• Registration Number: NL-OMON33315
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 140

Inclusion Criteria

age between 65 and 80 years diabetes patients: diagnosed with diabetes for more than 1 year

Exclusion Criteria

Dementia - TIA or non-invalidating stroke in the past 2 years or any invalidating stroke. - Other neurological diseases, unrelated to DM2, that are likely to affect cognition, including a history of brain trauma requiring hospitalisation - Known with or history of psychiatric disorders requiring hospitalisation or >12 months medication use (e.g. schizophrenia , Major depression (DSM IV)) - Contra-indication for 7 Tesla MR imaging (as established by the department)

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The prevalence and total number of microinfarcts and microbleeds at 7T in<br /><br>relation to DM2 status and cognition.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Microvascular lesion load will be related to cognition, conventional MR markers<br /><br>(atrophy, white matter hyperintensities), diabetes status and vascular risk<br /><br>factors.</p><br>