Microvascular lesions in the brain: a new perspective on cognitive impairment in type 2 diabetes
Withdrawn
- Conditions
- type 2 diabetes mellitus100126531001462310047075
- Registration Number
- NL-OMON33312
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 140
Inclusion Criteria
age between 65 and 80 years
diabetes patients: diagnosed with diabetes for more than 1 year
Exclusion Criteria
- Dementia
- TIA or non-invalidating stroke in the past 2 years or any invalidating stroke.
- Other neurological diseases, unrelated to DM2, that are likely to affect cognition, including a history of brain trauma requiring hospitalisation
- Known with or history of psychiatric disorders requiring hospitalisation or >12 months medication use (e.g. schizophrenia , Major depression (DSM IV))
- Contra-indication for 7 Tesla MR imaging (as established by the department)
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The prevalence and total number of microinfarcts and microbleeds at 7T in<br /><br>relation to DM2 status and cognition.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Microvascular lesion load will be related to cognition, conventional MR markers<br /><br>(atrophy, white matter hyperintensities), vascular and metabolic risk factors,<br /><br>brain connectivity parameters and cerebral blood flow.</p><br>