On the origin of cerebral small vessel disease
- Conditions
- cerebral small vessel diseasewhite matter hyperintensities100079631001227210003216
- Registration Number
- NL-OMON42650
- Lead Sponsor
- eurologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 50
Participants will be recruited from our ongoing RUNDMC study. The current proposal can be seen as an extension of the RUNDMC Study. Eligibility criteria for participation with the RUNDMC study included the presence of cerebral small vessel disease on neuroimaging (made because of symptoms of small vessel disease), age 50-85 years.
For the current extension the following inclusion criteria will be added:;- Above RUNDMC average progression of cerebral small vessel disease as assessed on sequential MRI scanning in 2006 and 2012.
- Have risk factors of progression
- Hypertension
- IADL > 6 (functionally independent)
- Being able to visit the research centre on a monthly basis
- Atrial fibrillation
- carotid artery stenosis > 50%
- Dementia
- Mild cognitive impairment
- Parkinsonism
- Diabetes
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>incident small vessel disease</p><br>
- Secondary Outcome Measures
Name Time Method <p>progression of small vessel disease<br /><br>cognitive decline<br /><br>motor decline</p><br>