The Effect of The Tranexamic Acid on The Amount of Bleeding In Patients Under Surgical Mandibular Fractures

Phase 3

• Conditions: Intraoperative bleeding.; Unintentional cut, puncture, perforation or haemorrhage during surgical and medical care

• Registration Number: IRCT2015051122204N1
• Lead Sponsor: Vice chancellor For Research Of Ahvaz Jundishapur University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

Inclusion Criteria: Patients undergoing bilateral mandibular fractures surgery.

Exclusion Criteria

Patients with subarachnoid hemorrhage; History of CVA (cerebrovascular accident definition); History of thrombosis; History of renal diseases and hematuria; Patients with bone disease; Patients with cleft lip and palate; Patients with craniofacial syndromes; History of Temporomandibular joint surgery; History of bone transplant recipient.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The amount of hemoglobin. Timepoint: Immediately before surgery and immediately after surgery. Method of measurement: Venous sampling and sent to the laboratory.;The amount of hematocrit. Timepoint: Immediately before surgery and immediately after surgery. Method of measurement: Venous sampling and sent to the laboratory.

Secondary Outcome Measures

Name	Time	Method
Bleeding (By calculating the difference between pre- and postoperative hemoglobin(Hb)). Timepoint: After surgery. Method of measurement: Using the formula: CBL= BV×(Hb loss/Hb per), Hb loss = Hb pre – Hb post + t(The number of injected packed red blood cell units).;Bleeding (By calculating the difference between pre- and postoperative hematocrit(Hct)). Timepoint: After surgery. Method of measurement: Using the formula: CBL = RBCL / [(HCTper+HCTpost)/2], RBCL = BV × (Hct pre – Hct post) + 320 t.