Study on the Administration of Tranexamic Acid or Placebo on the Rate of Perioperative Bleeding in Adult Patients Undergoing Liver Transplantation

Hospital de Clinicas de Porto Alegre0 个研究点开始时间: 2021年5月27日最近更新: 2023年5月29日

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•Only adult ASA III to IV patients, 18 to 70 years old, scheduled for liver transplantation at the Hospital de Clínicas de Porto Alegre, Santa Casa de Porto Alegre and Hospital das Clínicas Faculty of Medicine University of São Paulo.

•Patients with a history of acute arterial thrombosis or venous thromboembolism (<1 month), patients with a history of known thrombophilia, Budd-Chiari syndrome, primary biliary cholangitis, primary sclerosing cholangitis, patients with reduced left ventricular function ( ejection fraction <40%), pulmonary hypertension, preoperative pulmonary edema, or severe preoperative hemodynamic changes requiring the use of vasoactive drugs, planned use of tranexamic acid systemically during surgery, hypersensitivity or known allergy to acid tranexamic, history of seizure disorder, patients who have recently suffered a stroke or myocardial infarction (<1 month), patients with subarachnoid hemorrhage in the last 30 days and patients previously undergoing cranial neurosurgery. Patients with chronic dialysis kidney disease or patients in need of a liver-kidney transplant will also be excluded from the study.

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