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临床试验/NCT02191371
NCT02191371
已完成
不适用

Effect of Anesthetics on Oxygenation and Microcirculation During One-lung Ventilation

Seoul National University Hospital1 个研究点 分布在 1 个国家目标入组 104 人2014年7月

概览

阶段
不适用
干预措施
propofol
疾病 / 适应症
Mechanical Ventilation Complication
发起方
Seoul National University Hospital
入组人数
104
试验地点
1
主要终点
arterial partial pressure of oxygen
状态
已完成
最后更新
9年前

概览

简要总结

One-lung ventilation during thoracic surgery may affect systemic oxygenation and peripheral microcirculation by hypoxic pulmonary vasoconstriction. Both intravenous and inhalational anesthetics can be used during one-lung ventilation. However, there is still a controversy which anesthetic would be more appropriate during one-lung ventilation in the perspective of oxygenation and microcirculation. The investigators hypothesized that intravenous and inhalational anesthetics may affect oxygenation and microcirculation differently during one-lung ventilation.

详细描述

Patients undergoing thoracic surgery including one-lung ventilation will be randomized to receive intravenous (propofol) or inhalational (desflurane) anesthetic. Systemic oxygenation can be evaluated by measuring partial pressure of oxygen in arterial blood analysis. Microcirculatory parameters can be obtained from vascular occlusion test. Among those parameters, recovery slope during vascular occlusion test is known to reflect recruitment of microvasculature in response to hypoxic or ischemic insult. In this study, we will compare arterial partial pressure of oxygen and recovery slope during one-lung ventilation between propofol and desflurane group.

注册库
clinicaltrials.gov
开始日期
2014年7月
结束日期
2014年12月
最后更新
9年前
研究类型
Interventional
研究设计
Parallel
性别
All

研究者

责任方
Sponsor

入排标准

入选标准

  • undergoing thoracic surgery including one-lung ventilation

排除标准

  • refuse to enroll
  • BMI over 30 kg/m(2)
  • severe obstructive or restrictive lung disease
  • preoperative supplemental oxygen, intubated, or mechanical ventilatory support
  • preoperative arterial partial pressure of oxygen \< 60 mmHg
  • pregnancy
  • history of coronary artery disease
  • preoperative continuous infusion of vasopressor or inotropes
  • cannot undergo vascular occlusion test: anatomical abnormality of both arms, severe peripheral vascular disease, presence of A-V fistula

研究组 & 干预措施

propofol

Propofol is used as a maintenance anesthetic to patients in the propofol group. Intervention: propofol infusion by target-controlled infusion for maintaining anesthesia propofol (Fresofol MCT 2%) target effect site concentration: 4\~5 mcg/ml, during general anesthesia

干预措施: propofol

desflurane

Desflurane is used as a maintenance anesthetic to patients in the desflurane group. Intervention: Desflurane administration for maintaining anesthesia desflurane (Suprane) inhalation as 6\~8 vol% during general anesthesia

干预措施: desflurane

结局指标

主要结局

arterial partial pressure of oxygen

时间窗: 30 min after one-lung ventilation

Primary outcome is arterial partial pressure of oxygen 30 min after one-lung ventilation during thoracic surgery in propofol and desflurane groups.

次要结局

  • recovery slope(30 min after one-lung ventilation)

研究点 (1)

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