Effect of Anesthetics on Oxygenation and Microcirculation During One-lung Ventilation
概览
- 阶段
- 不适用
- 干预措施
- propofol
- 疾病 / 适应症
- Mechanical Ventilation Complication
- 发起方
- Seoul National University Hospital
- 入组人数
- 104
- 试验地点
- 1
- 主要终点
- arterial partial pressure of oxygen
- 状态
- 已完成
- 最后更新
- 9年前
概览
简要总结
One-lung ventilation during thoracic surgery may affect systemic oxygenation and peripheral microcirculation by hypoxic pulmonary vasoconstriction. Both intravenous and inhalational anesthetics can be used during one-lung ventilation. However, there is still a controversy which anesthetic would be more appropriate during one-lung ventilation in the perspective of oxygenation and microcirculation. The investigators hypothesized that intravenous and inhalational anesthetics may affect oxygenation and microcirculation differently during one-lung ventilation.
详细描述
Patients undergoing thoracic surgery including one-lung ventilation will be randomized to receive intravenous (propofol) or inhalational (desflurane) anesthetic. Systemic oxygenation can be evaluated by measuring partial pressure of oxygen in arterial blood analysis. Microcirculatory parameters can be obtained from vascular occlusion test. Among those parameters, recovery slope during vascular occlusion test is known to reflect recruitment of microvasculature in response to hypoxic or ischemic insult. In this study, we will compare arterial partial pressure of oxygen and recovery slope during one-lung ventilation between propofol and desflurane group.
研究者
入排标准
入选标准
- •undergoing thoracic surgery including one-lung ventilation
排除标准
- •refuse to enroll
- •BMI over 30 kg/m(2)
- •severe obstructive or restrictive lung disease
- •preoperative supplemental oxygen, intubated, or mechanical ventilatory support
- •preoperative arterial partial pressure of oxygen \< 60 mmHg
- •pregnancy
- •history of coronary artery disease
- •preoperative continuous infusion of vasopressor or inotropes
- •cannot undergo vascular occlusion test: anatomical abnormality of both arms, severe peripheral vascular disease, presence of A-V fistula
研究组 & 干预措施
propofol
Propofol is used as a maintenance anesthetic to patients in the propofol group. Intervention: propofol infusion by target-controlled infusion for maintaining anesthesia propofol (Fresofol MCT 2%) target effect site concentration: 4\~5 mcg/ml, during general anesthesia
干预措施: propofol
desflurane
Desflurane is used as a maintenance anesthetic to patients in the desflurane group. Intervention: Desflurane administration for maintaining anesthesia desflurane (Suprane) inhalation as 6\~8 vol% during general anesthesia
干预措施: desflurane
结局指标
主要结局
arterial partial pressure of oxygen
时间窗: 30 min after one-lung ventilation
Primary outcome is arterial partial pressure of oxygen 30 min after one-lung ventilation during thoracic surgery in propofol and desflurane groups.
次要结局
- recovery slope(30 min after one-lung ventilation)