Effect of Terlipressin for Intraoperative Blood Pressure Management in Kidney Transplantation

Not Applicable

Recruiting

• Conditions: Kidney Transplant; Delayed Graft Function; Intraoperative Hypotension
• Interventions: Drug: terlipressin

• Registration Number: NCT06855758
• Lead Sponsor: Beijing Friendship Hospital

Brief Summary

Prospective double blind randomized controlled trial. By randomizing patients undergoing kidney transplantation into a conventional catecholamine drug (dobutamine) blood pressure maintenance group and a terlipressin-complexed dobutamine group, the investigators compared the effect of intraoperative blood pressure maintenance and the dosage of the vasoactive drug, postoperative graft function, delayed graft function, and other related complications between the two groups, in order to demonstrate whether the use of terlipressin for blood pressure regulation during kidney transplantation is superior to the existing treatments.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-02
• Study First Submitted: 2025-02-27
• Study First Submitted QC: 2025-02-27
• Study First Posted: 2025-03-04
• Study Start: 2025-03-06
• Last Update Submitted: 2025-03-17
• Last Update Posted: 2025-03-20
• Primary Completion: 2027-06
• Study Completion: 2027-06

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• Patients with end-stage renal disease aged 18 years or above

Exclusion Criteria

• simultaneous multiple organ transplantation
• known allergy to study medication
• known pregnancy status
• cancellation of surgery due to grafts or personal reasons
• persistent severe preoperative hypertension that may not require intraoperative supportive therapy with vasoactive medications
• any other reason that the supervising physician or the anesthesiologist on duty think the patient is not suitable for the study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
terlipressin + dopamine	terlipressin	Terlipressin was given before the graft circulation was established while continuous using of dopamine during the whole operation

Primary Outcome Measures

Name	Time	Method
Delayed graft function	within the first 7 days after op	need kidney replacement in the first 7 days after op

Trial Locations

Locations (1)

Beijing Friendship Hospital; 🇨🇳 Beijing, China