Giessen Pulmonary Hypertension in Lung Cancer Registry
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- Measurements of the pulmonary artery diameter (PA) and ascending aorta (AA) diameter measured via computed tomography scan. PA and AA will be measured in millimeters.
研究概览
简要总结
The aim of this study is to investigate the frequency and implications of pulmonary hypertension in lung cancer patients. To do so, data will be collected from all lung cancer patients at the university hospital Giessen. All data will be analyzed for possible hints of pulmonary hypertension as a comorbidity in lung cancer patients. All information will be generated from the regular guidelines based course of treatment and there will be no interventions. This study will serve as a prospective register for all lung cancer patients treated at the university hospital Giessen.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient with lung cancer at the University of Giessen lung Cancer Center.
排除标准
- 未提供
结局指标
主要结局
Measurements of the pulmonary artery diameter (PA) and ascending aorta (AA) diameter measured via computed tomography scan. PA and AA will be measured in millimeters.
时间窗: 2 years
PA and AA will be combined to report the PA/AA quotient as indicator for pulmonary hypertension in all lung cancer patients. With a cut off value of ≥ 1 defining pulmonary hypertension.
6 Minute Walk Test in meters.
时间窗: 2 years
The 6 minute walk test is a sub-maximal exercise test used to assess aerobic capacity and endurance. The distance in meters covered over a time of 6 minutes is used as the outcome.
chronic obstructive pulmonary disease assessment test (CAT).
时间窗: 2 years
Scores on the CAT reach from 0-40, with higher scores indicating greater dyspnea.
Modified Medical Research Council Scale (mMRC).
时间窗: 2 years
Scores on the mMRC reach from 0-4, with higher scores indicating greater dyspnea.
sPAP values measured via Echocardiography.
时间窗: 2 years
systolic pulmonary artery pressure (sPAP) measured in millimetre of mercury (mmHg).
Overall Survival and Progression Free Survival measured in days.
时间窗: 2 years
Overall Survival and Progression free survival in days will be determined by Kaplan-Meier Analysis .Measuared in (st) (time from diagnosis to death)
Pulmonary function test measured via Spirometry.
时间窗: 2 years
vital capacity, total lung capacity, forced expiratory volume in one second, functional vital capacity, diffusing capacity for carbon monoxide, arterial partial pressure of oxygen; all measured as % of predicted normal values.
Body mass index.
时间窗: 2 years
weight and height will be combined to report BMI in kg/m\^2.
次要结局
未报告次要终点