A 6-year Follow-up Study of the Effect of Neurorehabilitation Training in Patients With Parkinson's Disease

Not Applicable

Completed

• Conditions: Parkinson Disease; Follow up; Rehabilitation
• Interventions: Other: Exercise+FU; Other: Active Comparator group Exercise

• Registration Number: NCT04559997
• Lead Sponsor: Somogy Megyei Kaposi Mór Teaching Hospital

Brief Summary

Individualization of exercise is recommended but rarely performed in patients with Parkinson's disease (PD). Unusually High Intensity and Individual Sensor Motor with Visuomotor Mobility Trainer The clinical symptoms, mobility and posture of PD patients. After 3 weeks of intensive treatment, treated patients and the control group were subjected to a two-year observation. Objectives: The effect of the unusually highly intense and strictly individualized sensomotor and visuomotor agility program was determined for the clinical symptoms, mobility and stability of non-demented PD patients with a two-year follow-up. Detection and comparison of results of patients undergoing biphasic maintenance with the results of intensively treated patients and the control group. Patients were recalled every 3 months after the first intensive examination and one year after a one-year control. The results of the active group were continuously compared with the results of the passive and control groups, thus determining the effectiveness of our treatment and the deterioration of the other groups in life-quality. The treated groups will be divided into two. One Parkinson's group takes part in a treadmill treatment that takes place 3 times a week for 6 years. The other group does not undergo a special series of exercises after 3 weeks of intensive therapy. Main outcome measures: Movement disorder Society Unified Parkinson Disease Rating Scale, Motor Experiences of Daily Living, a measure sensitive to changes in a broad spectrum of PD symptoms. In group time, repeated measurements of variance analysis were compared to MDS-UPDRS M-EDL, Beck Depression Score, PDQ-39, EQ5D VAS, Schwab \& England Scale for Parkinson's Disease. The TUG test and 12 static posturographic measurements are compared and compared to the healthy group as a standard. An at-limit and individualized sensorimotor and visuomotor agility exercise program vs. standard care, will improve non-demeted, stage 2-3 PD patient's clinical symptoms, mobility, and postural stability by functionally meaningful margins. As a long-term solution, a follow-up treatment can slow down the progression of clinical symtoms.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-09-01
• Primary Completion: 2020-09-01
• Study First Submitted: 2020-09-10
• Study First Submitted QC: 2020-09-22
• Study First Posted: 2020-09-23
• Status Verified: 2020-10
• Study Completion: 2020-10-01
• Last Update Submitted: 2020-10-13
• Last Update Posted: 2020-10-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 3

Inclusion Criteria

• Parkinson's disease
• Hoenh Yahr scale of 2-3
• Instability problem

Exclusion Criteria

• Severe heart problems
• Severe demeanor
• Alcoholism
• Drug problems

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Exercise+FU	Exercise+FU	Parkinson's group takes part in a treadmill treatment that takes place 3 times a week for 6 years.
Exercise	Active Comparator group Exercise	After 3 weeks of intensive treatment, no special exercises are performed as a control.

Primary Outcome Measures

Name	Time	Method
EQ5D-5L	6 years long	Questionnaire
posturography	6 year-long	body sway, Objective measurement of holding instability
Timed up and Go test	6 year-long	Measuring the speed of walking

Trial Locations

Locations (1)

Somogy Megyei Kaposi Mór Oktató Kórház; 🇭🇺 Kaposvár, Somogy, Hungary