Corosolic Acid and Cinnamon for the Treatment of the "Metabolic Syndrome" in Menopausal Transition Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 主要终点
- Changes in glycemia
研究概览
简要总结
This study evaluates the effect of a combination of glycirrhizic acid, Cinnamomun Zeylanicum and corosolic acid for the treatment of metabolic syndrome. Participants receive the supplement or a placebo.
详细描述
The supplement is composed by of a combination of glycirrhizic acid, Cinnamomun Zeylanicum and corosolic acid. They act in different way reducing insulin resistance, which is the main cause of metabolic syndrome. It was a randomized, controlled study involving 60 women with the metabolic syndrome following the criteria proposed by ATP III in 2015. Main outcomes were the improvement of the parameters that characterizes the metabolic syndrome, such as glucose and insulin levels, triglycerides, HDL-cholesterol and blood pressure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 45 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Postmenopausal women affected by Metabolic Syndrome, diagnosed by ATP 2015 criteria.
排除标准
- •treatment with steroids or with hypoglycemic or anti-cholesterol drugs
研究组 & 干预措施
Sineos
Glycyrrhizic acid 38 mg + Cinnamomum Zeylanicum 150 mg + corosolic acid 480 mcg 2 pills/day for 3 months
干预措施: Sineos (Dietary Supplement)
Placebo comparator
placebo 2 pills/day for 3 months
干预措施: Sineos (Dietary Supplement)
结局指标
主要结局
Changes in glycemia
时间窗: 3 months
Reduction of glycemia (mg/dl)
Changes in HDL-cholesterol
时间窗: 3 months
Increase of HDL-C (mg/dl)
次要结局
- changes in total-cholesterol(3 months)
- changes in triglycerides(3 months)
- changes in HOMA-IR(3 months)
研究者
Rosario D'anna
Principal Investigator, Clinical professor
University of Messina