NCT07679737进行中（未招募）不适用
The CPR, Pre-hospital ECPR and Early Reperfusion Study: A Target Trial Emulation (CHEER4TTE)
Australian and New Zealand Intensive Care Research Centre1 个研究点 分布在 1 个国家目标入组 250 人开始时间: 2025年1月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 250
- 试验地点
- 1
- 主要终点
- Survival to hospital discharge
研究概览
简要总结
CHEER4TTE is a target trial emulation, designed to simulate a randomised controlled trial by utilising data from pre-existing data sources. The aim is to determine whether prehospital ECPR for refractory out-of-hospital cardiac arrest improves the rate of survival to hospital discharge when compared to conventional cardiac arrest care.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Witnessed cardiac arrest
- •Bystander CPR
- •Refractory cardiac arrest (failure to achieve sustained ROSC >20 minutes)
- •Initial cardiac rhythm VF, VT or PEA
- •Within the hours of prehospital ECPR service operation
排除标准
- •Initial cardiac rhythm asystole
- •ROSC with sustained recovery
- •Unable to reach the patient and commence cannulation within 45 minutes of onset of arrest
- •Evidence of/suspected end-stage disease:
- •severe disability impairing activities of daily living
- •end-stage organ disease - cardiac, liver, lung, renal
- •other life-limiting diseases, e.g. malignancy, terminal illness
- •advance health care directive
- •Time periods of advanced public health restrictions in Victoria and NSW due to COVID-19
结局指标
主要结局
Survival to hospital discharge
时间窗: From meeting full eligibility criteria until the date/time of death or hospital discharge, assessed up to 180 days
次要结局
- ICU length of stay(From the date/time of ICU admission until the date/time of ICU discharge/death, assessed up to 180 days)
- Mechanical ventilation days(From date/time of mechanical ventilation commencement until date/time of liberation from mechanical ventilation assessed up to 180 days)
- ECMO complications(From the date/time of commencement of ECMO support until 1 week following the date/time of cessation of ECMO support)
- Rates of organ and tissue donation in non-survivors(In the 48hours following date/time of death)
- Low flow time(time from onset of arrest to time of ECPR flow, or time of death)
研究者
研究点 (1)
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