Evaluating effect of vitamin C on reducing harmful effect of radioiodine
Phase 4
- Conditions
- thyroid cancer.Malignant neoplasm of thyroid gland
- Registration Number
- IRCT2017041833505N1
- Lead Sponsor
- Vice Chancellor for research, Shiraz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
The patient has a suitable general condition; no kidney disease; radioiodine dose more than 150 millicuries; signing informed consent. Exclusion criteria:
The patient doesn't cooperate during intervention for taking the vitamin.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Catalase. Timepoint: Before and after intervention. Method of measurement: Reduce of absorption of H2O2 at 240nm by Spectrophotometric method.;Superoxide Dismutase. Timepoint: Before and after intervention. Method of measurement: Using Misra and Fridovich method based on the inhibition of spontaneous oxidation of adrenaline to adrenochrome by SOD in 10.2pH. Maximum light absorption of adrenochrome is at wavelength of 480nm.;Glutathione. Timepoint: Before and after intervention. Method of measurement: Using Elman method which DTNB is added to all of Super Natants and after that absorption in 412 nm is read.;Malondialdehyde. Timepoint: Before and after intervention. Method of measurement: Colorimetric method with a spectrophotometer at a wavelength of 532 nm and in nano gram per ml.
- Secondary Outcome Measures
Name Time Method