The effect of adjuvant vitamin C after varicocele surgery for improvement in sperm formation in infertile me

Phase 2

Conditions: Condition 1: Varicocele. Condition 2: Male infertility.
Scrotal varices
Male infertility

Registration Number: IRCT201103042134N2

Lead Sponsor: Vice chancellor for research, Arak University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: Male

Target Recruitment: 84

Inclusion Criteria

Palpable varicocele (grade 2 or 3) in physical examination; Abnormality in count, motility, or morphology of sperm in two separate semen analyses based on WHO criteria; No azoospermia; No major underlying disease such as: diabetes or hormonal abnormalities based on history and physical examination; Not smoker or addicted to any recreational drugs; Not using any drugs or supplements on a regular basis; Age between 18-50 years; Weight between 50-100 kg; No active or chronic genitourinary infection based on history, physical examination, urine analysis, and semen analysis; No previous history of peptic ulcer disease or vitamin C intolerance
Exclusion criteria: Patients' unwillingness to continue participation; Not attending follow up visits; Incorrect utilization of the capsules; Occurrence of side effects due to capsules; Late complications of surgery such as hydrocele, recurrence of varicocele, or testis atrophy; Commencement of smoking or addiction during the follow up

Exclusion Criteria

Not provided

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Sperm motility. Timepoint: Before and 3 months after the surgery. Method of measurement: Mean percent of motile sperm class A+B in two separate semen analyses.;Sperm count. Timepoint: Before and 3 months after the surgery. Method of measurement: Mean concentration of sperm in two separate semen analyses.;Sperm morphology. Timepoint: Before and 3 months after the surgery. Method of measurement: Mean percent of sperm with normal morphology based on WHO criteria in two separate semen analyses.

Secondary Outcome Measures